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INRAE
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Joakim LUNDEBERG

Professor, Department of Gene Technology, SciLifeLab

KTH Royal Institute of Technology, Sweden

Professor Joakim Lundeberg of the Department of Gene Technology focuses on molecular technology development. Since May 2010, his research group has been located at the Science for Life Laboratory (SciLifeLab), a national center for molecular biosciences with focus on health and environmental research. The center combines frontline technical expertise with advanced knowledge of translational medicine and molecular bioscience. His current research focus relates to spatially resolved gene expression studies in situ, Spatial Transcriptomics.  RNA-sequencing offers the possibility to analyze the expression of all genes in a sample. However, the spatial information of gene expression is lost. In the pioneering work a method was described that allowed studies of gene expression in tissue sections using RNA-sequencing to uncover transcriptional patterns in situ (Ståhl et al, Science, 2016). Applying this strategy has been demonstrated to work remarkably well and allows visualizing and quantifying the transcriptome in regular histological tissue sections, i.e. tissue domains can be matched to precise gene expression patterns. Furthermore, data driven methods can be applied to discover in an unsupervised manner transcriptomic patterns in space. Such patterns correspond to cell-types, microenvironments, or tissue components that allow for novel avenues of research.
Professor Lundeberg’s guest presentation will focus on Transcriptional landscape in the context of tissue morphology in health and disease