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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018


Principal Investigator

Stanford University School of Medicine California, USA

Joseph Foley is a research scientist at the Stanford University School of Medicine. In the laboratory of Prof. Robert B. West, he applies laser-capture microdissection and single-cell technologies to study the functional genomics of the tumor microenvironment in breast cancer. Dr. Foley has been pioneering molecular biology and bioinformatics techniques for next-generation sequencing since the early days of the technology. He carried out his dissertation research in with Prof. Arend Sidow at Stanford University, using a new approach in large-scale ChIP-seq analysis to map the behavior of dozens of transcription factors at high-occupancy target regions. At Stanford he also assisted in the development of 3SEQ, a streamlined gene-expression profiling method that is robust to RNA degradation. He expanded on this work in his postdoctoral research in neurogenomics with Prof. Michael Meaney at McGill University's Douglas Hospital Research Centre, where he combined 3SEQ with other recent innovations to create a much more efficient and sensitive method, Smart-3SEQ. He then returned to Stanford to adapt Smart-SEQ to tissue samples from laser-capture microdissection. Together these techniques unlock gene-expression profiling from very small samples of fixed archival tissue, including single cells, which enables new approaches in molecular pathology and histology-directed genomics.

Joe Foley will be presenting “Gene-expression profiling of single cells from archival tissue with laser-capture microdissection and Smart-3SE”