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24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018


Group leader

Human Technopole Institute (Italy) Karolinska Insitute and Science for Life Laboratory (Sweden)

@BienkoMagda; @BiCroLabs

Magda Bienko is a group leader at the Human Technopole Institute in Milan, Italy as well as Karolinska Institutet and Science for Life Laboratory in Stockholm, Sweden, where she leads her lab for Quantitative Biology of the Nucleus. As a principal investigator and as an ERC Starting Grant awardee, she contributed to developing a novel sequencing method for mapping DNA double-strand breaks along the genome (BLISS, Nature Communications 2017; Nature Protocols 2020), and pioneered the first genome-wide method for profiling radial distances in the nucleus (GPSeq, Nature Biotechnology 2020). She has also built open-access resources for high-resolution DNA and RNA fluorescence in situ hybridization (iFISH, Nature Communications 2019), which her group is routinely using to study genome organization and gene expression at single cell resolution.

The Bienko Lab aims at understanding the design principles and mechanisms that shape the spatial arrangement of DNA, RNAs and proteins in the nucleus of mammalian cells. They investigate how the three-dimensional (3D) architecture of the genome instructs and/or is instructed by fundamental processes including DNA replication, transcription, and repair. The lab is also interested in understanding how mutations and genomic alterations associated with prevalent disorders like cancer form in the context of the 3D genome and, in turn, how they perturb the 3D genome structure and functions to exert their pathogenic effects.