Daan Noordermeer obtained his PhD in 2009 from the Erasmus University (Rotterdam, The Netherlands), working with Wouter de Laat and Frank Grosveld on the 3D genome organization of the mouse beta-globin locus. He then moved to the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland) for a postdoc with Denis Duboule. Here, he was among the first to report an intimate link between 3D genome organization, histone modifications and gene regulation (Noordermeer et al., Science 2011). Since 2014, he is a tenured researcher at the CNRS (French National Center for Scientific Research) and he heads the Chromatin Dynamics group at the I2BC (Institute for Integrative Biology of the Cell, Gif-sur-Yvette - France). With his team, he continues the investigation into the links between genome structure and epigenetic mechanisms using a mix of genomics and single-cell approaches in the context of stem cells, aging and cancer.